Virus Quiz : Test your knowledge

Virus Quiz (UPSC Prelims Level)

Choose the correct option for each question. Click “Show Answer” to reveal and hide it again.

1. With reference to viruses, which of the following statements is/are correct?

  1. All viruses are obligate intracellular parasites.
  2. All viruses contain both DNA and RNA as genetic material.
  3. Some viruses can be crystallized outside the host cell.

Select the correct answer using the code below:

  1. 1 only
  2. 1 and 3 only
  3. 2 and 3 only
  4. 1, 2 and 3
Correct answer: B – 1 and 3 only. All viruses are obligate intracellular parasites, but an individual virus has either DNA or RNA, not both. Some can be crystallized outside the host.

2. Consider the following statements regarding RNA viruses:

  1. They mutate generally faster than DNA viruses.
  2. All RNA viruses necessarily have an envelope.
  3. Some RNA viruses can directly serve as mRNA inside host cells.

Which of the statements given above is/are correct?

  1. 1 only
  2. 1 and 3 only
  3. 2 and 3 only
  4. 1, 2 and 3
Correct answer: B – 1 and 3 only. RNA viruses mutate faster due to error-prone polymerases and some (+) sense RNA viruses act directly as mRNA. Not all RNA viruses are enveloped.

3. Which of the following best describes a retrovirus?

  1. A DNA virus that replicates entirely in the cytoplasm.
  2. An RNA virus that uses reverse transcriptase to form DNA in the host cell.
  3. A virus that infects only bacteria.
  4. A virus that lacks a protein coat.
Correct answer: B – Retroviruses (such as HIV) are RNA viruses that use the enzyme reverse transcriptase to synthesize DNA from RNA inside host cells.

4. With reference to bacteriophages, which of the following statements is/are correct?

  1. They infect bacterial cells and may follow either lytic or lysogenic cycles.
  2. They are used as tools in molecular biology and genetic engineering.
  3. They are incapable of transferring bacterial genes between bacteria.

Select the correct answer using the code below:

  1. 1 and 2 only
  2. 2 and 3 only
  3. 1 and 3 only
  4. 1, 2 and 3
Correct answer: A – 1 and 2 only. Bacteriophages can follow lytic or lysogenic cycles and are important tools in genetics. They can transfer bacterial genes by transduction, so statement 3 is incorrect.

5. Which of the following best explains why antibiotics are generally ineffective against viral infections?

  1. Viruses lack the metabolic pathways and cell wall targets that antibiotics act upon.
  2. Viruses are too small to be detected by antibiotics.
  3. Viruses become immediately dormant in human tissues.
  4. Viruses are always resistant to all chemical agents.
Correct answer: A – Antibiotics act on bacterial cell wall synthesis, protein synthesis and other metabolic pathways, which viruses lack because they rely on the host cell machinery.

6. In the context of public health, “herd immunity” against a viral disease depends primarily on which of the following?

  1. Proportion of immune individuals in the population.
  2. Basic reproduction number (R₀) of the virus.
  3. Ability of the virus to survive outside the host indefinitely.

Which of the statements given above is/are correct?

  1. 1 only
  2. 1 and 2 only
  3. 2 and 3 only
  4. 1, 2 and 3
Correct answer: B – 1 and 2 only. Herd immunity depends on how many people are immune and the R₀ of the virus. Environmental survival influences transmission but is not a direct parameter in herd immunity thresholds.

7. Consider the following pairs:

Virus – Primary mode of transmission

  1. Hepatitis B virus – Blood and body fluids
  2. Rabies virus – Faeco-oral route
  3. Influenza virus – Respiratory droplets
  4. Human papillomavirus (HPV) – Vector-borne

Which of the pairs given above is/are correctly matched?

  1. 1 and 3 only
  2. 1, 2 and 3 only
  3. 2 and 4 only
  4. 1, 3 and 4 only
Correct answer: A – 1 and 3 only. Hepatitis B spreads mainly via blood/body fluids; influenza via respiratory droplets. Rabies is transmitted chiefly by bites (saliva), and HPV is primarily sexually transmitted, not vector-borne.

8. With reference to viral vaccines, which of the following statements is/are correct?

  1. Live attenuated vaccines generally induce stronger and longer-lasting immunity than inactivated vaccines.
  2. Inactivated vaccines can be safely given to severely immunocompromised individuals in most cases.
  3. Both live attenuated and inactivated viral vaccines always provide sterilizing immunity.

Select the correct answer using the code below:

  1. 1 only
  2. 1 and 2 only
  3. 2 and 3 only
  4. 1, 2 and 3
Correct answer: B – 1 and 2 only. Live attenuated vaccines mimic natural infection and often give stronger immunity; inactivated vaccines are usually safer in immunocompromised hosts. Not all vaccines provide sterilizing immunity.

9. In the context of viral replication, what does the “latent period” refer to?

  1. The time from viral entry into a host organism to the first appearance of clinical symptoms.
  2. The time from viral entry into a single host cell until mature virions are first released.
  3. The duration for which a virus remains viable on inanimate surfaces.
  4. The cumulative time taken for viral genetic material to integrate into the host genome.
Correct answer: B – In virology, the latent period is the time between entry of the virus into a cell and the first release of new virions, distinct from the incubation period of disease.

10. Which of the following characteristics can help distinguish viruses from prions?

  1. Presence of nucleic acid as genetic material.
  2. Ability to be inactivated by agents that degrade nucleic acids.
  3. Exclusive proteinaceous nature without any nucleic acid.

Select the correct answer using the code below:

  1. 1 only
  2. 1 and 2 only
  3. 2 and 3 only
  4. 1, 2 and 3
Correct answer: B – 1 and 2 only. Viruses have nucleic acids and can be affected by nucleic acid–degrading agents. Prions are misfolded proteins without nucleic acid (statement 3 describes prions, not viruses).

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